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OncoMRD BREAST for Monitoring Minimal Residual Disease in Breast Cancer: A Megadata Large-Scale Retrospective Clinical Correlation Study

2026-05-27

Abstract excerpt

<h4>Background: </h4> ctDNA-based NGS MRD testing in breast cancer faces a critical but overlooked limitation: low-frequency somatic mutations from normal aging non-malignant tissues—beyond clonal hematopoiesis—contaminate plasma ctDNA at levels indistinguishable from true MRD signals, creating a specificity ceiling that increased sequencing depth cannot resolve. The OncoMRD BREAST panel, an 11-gene transcriptomic...

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Literature Corpus work
7cf61107-6958-5268-8c22-705e5bdf097c
DOI
10.20944/preprints202605.1803.v1
Open publication

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OncoMRD BREAST for Monitoring Minimal Residual Disease in Breast Cancer: A Megadata Large-Scale Retrospective Clinical Correlation StudyDOI 10.20944/preprints202605.1803.v1
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