Article
AI-Generated Hallmarks of Aging and Cancer: A Computational Approach Using Causal Emergence and Dependency Networks
2024-08-30
Abstract excerpt
This study introduces “hallmarks engineering,” a computational approach to generate quantifiable hallmarks of aging and cancer. We evaluated these hallmarks using genome-wide DNA methylation data from ten age-related diseases. Causal emergence analysis revealed that hallmark-level features show stronger disease associations than individual genes, with improvements up to 9.7 orders of magnitude. Hallmark-based mode...
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Identifiers and source
- Literature Corpus work
- 7cc3a54e-a3cb-5b64-a0b0-4bec5cbb4c44
- DOI
- 10.1101/2024.08.28.610200