Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validation

4 Jul 2025

Abstract excerpt

BACKGROUND: Ageing is a multifactorial process closely associated with increased risk of chronic diseases. While epigenetic clocks have advanced ageing research, most rely on isolated CpG sites, limiting biological interpretability. We developed PathwayAge, a biologically informed model that captures coordinated methylation changes at the pathway level, providing interpretable insights into ageing biology and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40616903
DOI: 10.1016/j.ebiom.2025.105829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validationPMID 40616903Read ↗

Next Generation Aging Clock: A Novel Approach to Decoding Human Aging Through Over 3000 Cellular PathwaysSemantic proximity Read ↗

Making Biological Ageing Clocks PersonalSemantic proximity Read ↗

DNA methylation clocks for estimating biological age in Chinese cohortsSemantic proximity Read ↗

An epigenetic clock for chronological age estimation in East Asian populationsSemantic proximity Read ↗

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease riskSemantic proximity Read ↗

Multi-omic underpinnings of epigenetic aging and human longevity.Semantic proximity Read ↗

Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAgeSemantic proximity Read ↗

Current perspectives on the cellular and molecular features of epigenetic ageingSemantic proximity Read ↗

AI-Generated Hallmarks of Aging and Cancer: A Computational Approach Using Causal Emergence and Dependency NetworksSemantic proximity Read ↗

AI-Generated Hallmarks of Aging and Cancer: A Computational Approach Using Causal Emergence and Dependency NetworksSemantic proximity Read ↗

Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity Read ↗

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical recordsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.