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Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocks

2025-09-12

Abstract excerpt

Scientific discovery has long relied on human creativity, with computation limited to analysis. Here we report an AI-guided system, K-Dense, that accelerates hypothesis testing and delivers robust scientific discoveries. Trained on ARCHS4 (57,584 samples, 28 tissues, 1,039 cohorts, ages 1–114), the unified ensemble clock achieved R 2 = 0.854 and MAE = 4.26 years—while uniquely providing calibrated confidence inte...

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Identifiers and source

Literature Corpus work
0450d986-69f4-53c6-ad39-8858442bd4be
DOI
10.1101/2025.09.08.674588
Open publication

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Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocksDOI 10.1101/2025.09.08.674588
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