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Article

Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability.

Journal of neurophysiology - 1 Dec 2005

Wang Yue, Nicol G D, Clapp D Wade, Hingtgen Cynthia M

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by tumor formation. People with NF1 also can experience more intense painful responses to stimuli, such as minor trauma, than normal. NF1 results from a heterozygous mutation of the NF1 gene, leading to decreased levels of neurofibromin, the protein product of the NF1 gene. Neurofibromin is a guanosine triphosphatase activating protein...

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Identifiers

PMID: 16093333
DOI: 10.1152/jn.00489.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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