Article

Creation of X-linked Alport Syndrome Rat Model with <i>Col4a5</i> Deficiency

2021-04-14

Abstract excerpt

<h4>Summary</h4> Alport syndrome is an inherited chronic human kidney disease, characterized by glomerular basement membrane abnormalities. This disease is caused by mutations in COL4A3, COL4A4 , or COL4A5 gene. The knockout mice for Col4α3, Col4α4 , and Col4α5 are developed and well characterized for the study of Alport syndrome. However, disease progression and effects of pharmacological therapy depend on t...

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Literature Corpus work: 7ca8faaa-476d-5347-969d-5cfaf7bdd334
DOI: 10.1101/2021.04.13.439726

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