Implications of the 375W mutation for HIV-1 tropism and vaccine development

Abstract excerpt

HIV-1 vaccines need to induce broadly neutralizing antibodies (bnAb) against conserved epitopes in the envelope glycoprotein (Env) to protect against diverse HIV-1 clades. To achieve this, we need to understand how different amino acids affect the Env trimer structure to find a common strategy to readily produce Env vaccines of different subtypes. Previously, using a saturation mutagenesis strategy we identified s...

Topics

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• Broadly Neutralizing Antibodies
• CD4 Antigens
• env Gene Products, Human Immunodeficiency Virus
• HIV-1
• HIV Antibodies
• HIV Infections
• Macrophages
• Viral Tropism

Identifiers and source

Literature Corpus work

7c8c0fb6-5405-5e19-9e2e-4e52e727955d

DOI

10.1101/2022.08.29.505747