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Analytic Choices Shape Genomic Risk Estimates from Electronic Health Records: Coronary Heart Disease in eMERGE IV

2026-04-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Electronic health records (EHR) are an important data source for genomic studies, but challenges exist in ascertaining cases and observation start time. We used data derived from the Electronic Medical Records and Genomics (eMERGE) IV study to examine how analytic assumptions regarding case ascertainment and EHR entry time influence estimation of monogenic and polygenic risk...

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Literature Corpus work
7c665d39-9190-5369-bd57-3b7a491de97a
DOI
10.64898/2026.04.28.26352002
Open publication

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Analytic Choices Shape Genomic Risk Estimates from Electronic Health Records: Coronary Heart Disease in eMERGE IVDOI 10.64898/2026.04.28.26352002
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