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Measuring the accuracy of electronic health record (EHR)-based phenotyping in the <i>All of Us</i> Research Program to optimize statistical power for genetic association testing

2025-07-31

Abstract excerpt

Accurate phenotyping is an essential task for researchers utilizing electronic health record (EHR)-linked biobank programs like the All of Us Research Program ( AoU ) to study human genetics. While their large cohort sizes offer increased statistical power for detecting novel risk alleles, those benefits are undermined if participants’ disease status cannot be accurately determined from EHRs. Little guidance is av...

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Literature Corpus work
39161254-7fed-5180-accd-e9f340cc0f8a
DOI
10.1101/2025.07.30.25332455
Open publication

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Measuring the accuracy of electronic health record (EHR)-based phenotyping in the <i>All of Us</i> Research Program to optimize statistical power for genetic association testingDOI 10.1101/2025.07.30.25332455
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