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High-throughput analysis system of interaction kinetics for data-driven antibody design

21 Nov 2023

Abstract excerpt

Surface plasmon resonance (SPR) is widely used for antigen-antibody interaction kinetics analysis. However, it has not been used in the screening phase because of the low throughput of measurement and analysis. Herein, we proposed a high-throughput SPR analysis system named "BreviA" using the Brevibacillus expression system. Brevibacillus was transformed using a plasmid library containing various antibody...

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PMID: 37990030
DOI: 10.1038/s41598-023-46756-y

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