Article

Neuropilin 1 and Neuropilin 2 Gene Invalidation or Pharmacological Inhibition Reveals Their Relevance for the Treatment of Metastatic Renal Cell Carcinoma

2020-12-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent ®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs coreceptors, Neuropilins 1, 2 (NRP1, 2) are expressed on sev...

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Literature Corpus work: 7c3f9ef0-86b1-59f0-882b-9e351313af66
DOI: 10.21203/rs.3.rs-135601/v1

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