Article

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

2024-08-19

Abstract excerpt

Obesity is a debilitating disease with increasing worldwide prevalence. Despite its high prevalence, specific pharmacologic intervention for obesity is challenging. Here, we report that halofuginone, an FDA-approved anti-scleroderma and anti-protozoal drug, is a promising anti-obesity agent in rodent models. Halofuginone suppressed food intake, increased energy expenditure, and resulted in weight loss in preclinic...

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Literature Corpus work: 7b72d00b-67ce-53d2-892e-2165b41368d1
DOI: 10.1101/2024.08.18.608423

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