Article

Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity

2020-07-09

Abstract excerpt

<h4>Background: </h4> : HSG4112 is a clinical-stage drug candidate for the treatment of obesity. Here, we report its discovery and preclinical efficacy. <h4>Methods: </h4> : In high-fat diet (HFD)-induced obese male C57BL/6J mice, we tested the weight loss effect of synthetic compounds derived from a structure-activity relationship (SAR) study of glabridin, a natural compound known to reduce body weight and inf...

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Literature Corpus work: 2908a994-c97b-5f58-a17b-4aa70874c0d0
DOI: 10.22541/au.158282438.81737534/v2

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