Article

CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes

2018-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils through its ITIM receptor. We now show that the prompt secretion of IL-6 in response to LPS is regulated by CEACAM1 expression on bone marrow monocytes. Ceacam1 -/- mice over-produce IL-6 in...

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Literature Corpus work: 7b47b680-77d2-51d7-8b07-ac915a7aeef1
DOI: 10.1101/394577

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