Article

A Variational Autoencoder Model for Clustering of Cell Nuclei on Microgroove Substrates: Potential for Disease Diagnosis

2024-12-27

Abstract excerpt

<h4>ABSTRACT</h4> Various diseases including laminopathies and certain types of cancer are associated with abnormal nuclear mechanical properties that influence cellular and nuclear deformations in complex environments. Recently, microgroove substrates designed to mimic the anisotropic topography of the basement membrane have been shown to induce significant 3D nuclear deformations in various adherent cell types....

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Literature Corpus work: 7b0781d8-2a02-5ccd-9125-fddc83a80d5b
DOI: 10.1101/2024.12.27.630482

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