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The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and Hypoxia-inducible factor 1-alpha

2024-01-31

Abstract excerpt

<h4>Background: </h4> Acute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) + Daunorubicin (DNR)), is accompanied by frequent relapses. Many factors are involved in causing chemoresistance. Heme Oxygenase-1 (HO-1) and Hypoxia-Inducible Factor 1-alpha (HIF-1α) are two of the most well-known genes, reported to be overexpressed in AML and promote resistance aga...

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Literature Corpus work
7aaec5e2-ffcc-588d-bae4-d528d7588ca3
DOI
10.21203/rs.3.rs-3902361/v1
Open publication

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The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and Hypoxia-inducible factor 1-alphaDOI 10.21203/rs.3.rs-3902361/v1
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