Article

Role of 2′-Hydroxycinnamaldehyde In The Induction of Apoptosis Via A Reactive Oxygen Species-Dependent JNK Pathway in Human Promyelocytic HL-60 Leukemia Cells

2021-05-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Because the role and molecular mechanism of 2′-hydroxycinnamaldehyde (2′-HCA) in human leukemia need to be clarified, we provide detailed insights into the mechanism underlying the anti-proliferative properties of 2′-HCA in acute myeloid leukemia (AML).<bold>Methods: </bold>We performed MTT assay to examine the cytotoxic effect of 2′-HCA. 2′-HCA-induced apoptoti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c319a292-e6c2-56f8-b6b1-0bfc0809fc6d
DOI: 10.21203/rs.3.rs-497892/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of 2′-Hydroxycinnamaldehyde In The Induction of Apoptosis Via A Reactive Oxygen Species-Dependent JNK Pathway in Human Promyelocytic HL-60 Leukemia CellsDOI 10.21203/rs.3.rs-497892/v1Read

D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)Semantic proximity Read

Induction of Apoptosis by Three Marine Algae through Generation of Reactive Oxygen Species in Human Leukemic Cell LinesSemantic proximity Read

Harmol induces apoptosis by caspase-8 activation independently on Fas/Fas ligand interaction in human lung carcinoma H596 cellsSemantic proximity Read

Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-β signaling pathway.Semantic proximity Read

A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitorSemantic proximity Read

5-Hydroxy-3,6,7,8,3‘,4‘-hexamethoxyflavone Induces Apoptosis through Reactive Oxygen Species Production, Growth Arrest and DNA Damage-Inducible Gene 153 Expression, and Caspase Activation in Human Leukemia CellsSemantic proximity Read

Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal KinaseSemantic proximity Read

Inhibition of cell proliferation and induction of apoptosis in K562 human leukemia cells by the derivative (3-NpC) from dihydro-pyranochromenes familySemantic proximity Read

Meripilus giganteus ethanolic extract exhibits pro-apoptotic and anti-proliferative effects in leukemic cell linesSemantic proximity Read

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure–Activity RelationshipsSemantic proximity Read

Centella asiatica fraction-3 suppresses Nrf-2 antioxidant pathway and enhances apoptotic cell death in HEK293 kidney cellsSemantic proximity Read