Article

Arginine Deprivation induces ROS Dependent Autophagic Cell Death in Human Acute Myeloid Leukemia Cells

2025-12-23

Abstract excerpt

<title>Abstract</title> <p>In this study, we assess the activation of autophagy and its impact on cytotoxicity following [HuArgI (Co)-PEG5000]-induced arginine deprivation in AML cells. We have previously shown that arginine deprivation is selectively cytotoxic to AML cells and that cell death is caspase independent and non-apoptotic, hence the mechanism of cell death remained elusive. We tested a panel of 6 AML...

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Literature Corpus work: fad1cf73-32a2-5081-b47c-9cb6261bb6c7
DOI: 10.21203/rs.3.rs-8358552/v1

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