Back to search

Article

Targeting NIK-mediated Microglial Polarization: A Novel Therapeutic Strategy for Diabetic Retinopathy

2026-04-10

Abstract excerpt

<title>Abstract</title> <p>Background Diabetic retinopathy (DR) is a sight-threatening microvascular complication characterized by blood-retina barrier (BRB) disruption. While inflammation is central to early DR, the role of the non-canonical NF-κB pathway remains poorly understood. Methods We established a murine DR model and performed RNA-seq. Retinal microglial activation and the expression of NF-κB-inducing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7a844811-2cd8-5292-94da-e3205c79360d
DOI
10.21203/rs.3.rs-9238909/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting NIK-mediated Microglial Polarization: A Novel Therapeutic Strategy for Diabetic RetinopathyDOI 10.21203/rs.3.rs-9238909/v1
Single-Cell Transcriptome Profiling Reveals the Suppressive Role of Retinal Neurons in Microglia Activation Under Diabetes MellitusSemantic proximity
Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathySemantic proximity
Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic RetinopathySemantic proximity
Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisationSemantic proximity
Roflumilast attenuates neuroinflammation post retinal ischemia/reperfusion injury by regulating microglia phenotype via the Nrf2/STING/NF-κB pathway.Semantic proximity
RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathySemantic proximity
IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity
Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.Semantic proximity
Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosaSemantic proximity
Single-cell transcriptomic analysis revealing changes in retinal cell subpopulation levels and the pathways involved in diabetic retinopathySemantic proximity
Cytokine-Driven NF-κB Activation in Retinal Cells and Its Impact on the Pathogenesis of Age-Related Macular Degeneration: A Systematic ReviewSemantic proximity
Bulk Gene Expression Deconvolution Reveals Infiltration of M2 Macrophages in Retinal NeovascularizationSemantic proximity
Select a neighboring publication to make it the new centre.