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Massive reduction of RyR1 in muscle spindles of mice carrying recessive <i>Ryr1</i> mutations alters proprioception and causes scoliosis

2024-08-09

Abstract excerpt

Muscle spindles are stretch receptors lying deep within the muscle belly involved in detecting changes in muscle length and playing a fundamental role in motor control, posture and synchronized gait. They are made up of an external capsule surrounding 3-5 intrafusal muscle fibers and a nuclear bag complex. Dysfunction of muscle spindles leads to abnormal proprioceptor function, which has been linked to aberrant bo...

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Literature Corpus work
7a51209e-2871-502e-b897-a5c4435d7d8f
DOI
10.1101/2024.08.09.607317
Open publication

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Massive reduction of RyR1 in muscle spindles of mice carrying recessive <i>Ryr1</i> mutations alters proprioception and causes scoliosisDOI 10.1101/2024.08.09.607317
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