Article

Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.

2025-04-02

Abstract excerpt

<title>Abstract</title> <p>Older adults are particularly vulnerable to infectious diseases, and vaccines are often less effective in this population due to immunosenescence, which is characterized by diminished B and T memory responses. Autophagy is believed to underlie many facets of cellular aging, including immunosenescence. It is crucial for maintaining memory T and B cell functions but declines with age, alo...

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Literature Corpus work: 7a449013-9bf8-538e-aa61-3c15118336bc
DOI: 10.21203/rs.3.rs-5686388/v1

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