Three doses of Sars-CoV-2 mRNA vaccine in older adults result in similar antibody responses but reduced cellular cytokine responses relative to younger adults

Abstract excerpt

• No increase in cytokine producing T cells was observed after the booster vaccination in the elderly. • The elderly had higher plasma levels of soluble T-cell activation/exhaustion markers that correlated inversely with age and T-cell responses. • Booster vaccination was needed in older adults to increase memory B cells to the SARS-CoV-2 receptor binding domain. • SARS-CoV-2 mRNA vaccine booster increases...

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