Article

Discovery of BRCA1/BRCA2 Founder Variants by Haplotype Analysis

2021-07-26

Abstract excerpt

A significant number of hereditary breast or ovarian cancers are caused by germline variants, mostly BRCA1/BRCA2 genes. Because genetic predispositions vary by ethnicity, several studies have reported founder variants of BRCA1/BRCA2 genes. Such founder variants were reported primarily based on their relevant population frequencies. We reviewed the variant data relating to BRCA1 and BRCA2 genes from January, 2012 t...

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Literature Corpus work: 79223690-98a7-5aee-8e88-add94093ef82
DOI: 10.21203/rs.3.rs-734551/v1

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