Article

Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer’s disease

2020-11-03

Abstract excerpt

Alzheimer’s disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity mediated by gene repression factors SUZ12 and REST. AD individuals with abnormal t-tau levels have increased CSF concentra...

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Identifiers and source

Literature Corpus work: 7909ad24-6080-5989-b8c6-785e2bc46095
DOI: 10.1101/2020.10.29.20211920

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