Article
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model
2020-08-19
Abstract excerpt
Synchronous metastatic melanoma, clinically defined as multiple lesions diagnosed within 6 months, has a poor prognosis. Despite recent advances in systemic immunotherapy, a majority of patients fail to respond or exhibit lesion-specific responses. While intertumoral heterogeneity has been clinically associated with lesion-specific therapeutic responses, no clear mechanism has been identified, largely due to the s...
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Identifiers and source
- Literature Corpus work
- 78bae77d-bedf-5e1e-851d-32695f2d6608
- DOI
- 10.1101/2020.08.18.216259