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Article

An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population.

Journal of the American Heart Association - 3 Apr 2017

Cheng Jianding, Kyle John W, Lang Di, Wiedmeyer Brandi, Guo Jian, Yin Kun, Huang Lei, Vaidyanathan Ravi, Su Terry, Makielski Jonathan C

Abstract excerpt

BACKGROUND: We have identified the cardiomyopathy-susceptibility gene vinculin (VCL) mutation M94I may account for a sudden unexplained nocturnal death syndrome (SUNDS) case. We addressed whether VCL common variant D841H is associated with SUNDS. METHODS AND RESULTS: In 8 of 120 SUNDS cases, we detected an East Asian common VCL variant p.Asp841His (D841H). Comparing the H841 allele frequency of the general...

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Identifiers

PMID: 28373245
DOI: 10.1161/JAHA.116.005330
PMCID: PMC5533021

Genes

VCL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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