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Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus

30 Oct 2009

Abstract excerpt

Environmental factors are capable of triggering the expression of human endogenous retroviruses and induce an autoimmune response. Infection can promote the expression of human endogenous retroviruses by molecular mimicry or by functional mimicry. There are additional mechanisms which may control the expression of human endogenous retroviruses, such as epigenetic status of the genome (hypomethylation, histone...

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PMID: 19880559
DOI: 10.1177/0961203309345728

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