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Targeted Delivery of cGAS Inhibitor Ru.521 to Macrophages Attenuates Immune Rejection Following Renal Transplantation

2026-01-23

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<title>Abstract</title> <p>Ischemia–reperfusion injury (IRI) during renal transplantation triggers sterile inflammation and activates the cGAS–NF-κB/IRF3 axis, thereby promoting macrophage and T-cell–mediated rejection. However, systemic cGAS inhibition carries risks of off-target immunosuppression and infection. Here, we combined bulk and single-cell transcriptomic analyses (GSE157292, GSE268009, GSE257542) with...

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Literature Corpus work
78827ee1-13c3-5e08-a762-9b2e374ca80d
DOI
10.21203/rs.3.rs-8634004/v1
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Targeted Delivery of cGAS Inhibitor Ru.521 to Macrophages Attenuates Immune Rejection Following Renal TransplantationDOI 10.21203/rs.3.rs-8634004/v1
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