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The proton pump inhibitor omeprazole does not promote <i>Clostridioides difficile</i> colonization in a murine model

2019-09-19

Abstract excerpt

Proton pump inhibitor (PPI) use has been associated with microbiota alterations and susceptibility to Clostridioides difficile infections (CDIs) in humans. We assessed how PPI treatment alters the fecal microbiota and whether treatment promotes CDIs in a mouse model. Mice receiving a PPI treatment were gavaged with 40 mg/kg of omeprazole during a 7-day pretreatment phase, the day of C. difficile challenge, and t...

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Literature Corpus work
78714f76-ff92-5e89-b6d2-88fdca2608f1
DOI
10.1101/775411
Open publication

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The proton pump inhibitor omeprazole does not promote <i>Clostridioides difficile</i> colonization in a murine modelDOI 10.1101/775411
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