Article

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

2019-10-18

Abstract excerpt

<h4>Purpose</h4> Immune checkpoint inhibitors (ICI) have demonstrated promising therapeutic benefit although a majority will not respond. Here we identify and validate predictive biomarkers from plasma-derived exosomes that allow non-invasive monitoring of tumor intrinsic and host immune status and prediction of ICI success. <h4>Experimental Design</h4> Transcriptomic profiling of peripheral blood bulk exosomes...

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Literature Corpus work: 783ef222-7513-596b-895e-e0fdddcd01fa
DOI: 10.1101/809699

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