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Article

Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1

13 Jan 2022

Abstract excerpt

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and this is indispensable for oocyte development and female fertility. Although the role of macroautophagy/autophagy in ovarian function has been reported, its contribution to the regulation of GC characteristics remains elusive. The siRNA-mediated knockdown of two key autophagy-related genes ATG5 and BECN1 and the autophagy...

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PMID: 35025698
DOI: 10.1080/15548627.2021.2005415

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