Genomics and Antimicrobial Drug Discovery

Abstract excerpt

The increasing frequency of nosocomial infections due to methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) and the fear that high-level vancomycin resistance will eventually spread to staphylococci underscore the need for vigilance in the continuing war against pathogenic microbes (18, 39). Current widely used antibiotics are targeted at a surprisingly small...