Article

Design of vaccine nanotechnology-based delivery systems : the effect of CpGODN TLR9 agonist-protein antigen conjugates anchored to liposomes

2020-01-01

Abstract excerpt

The efficiency of CpG oligonucleotides as Toll like receptor (TLR) 9 agonist has been well established along the last few years. Although CpGODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, its in vivo stability and potential systemic toxicity have generated concern for the use of CpGODN. In an effort to increase stability, localise action and reduce dosage, different strate...

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Literature Corpus work: 77bf3623-bb23-55f9-8b74-a29d324e71ee
DOI: 10.48730/c254-7a24

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