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Variance in Variants: Propagating Genome Sequence Uncertainty into Phylogenetic Lineage Assignment

2021-12-02

Abstract excerpt

Genetic sequencing is subject to many different types of errors, but most analyses treat the resultant sequences as if they are known without error. Next generation sequencing methods rely on significantly larger numbers of reads than previous sequencing methods in exchange for a loss of accuracy in each individual read. Still, the coverage of such machines is imperfect and leaves uncertainty in many of the base c...

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Literature Corpus work: 77a5f490-b0af-5be3-8de0-16664aa20789
DOI: 10.1101/2021.11.30.470642

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