Article

Angio-Associated Migratory Cell Protein (AAMP) Regulates the Hippo/YAP Pathway and Mitochondrial Functionality to Drive Osteosarcoma Metastasis

2022-01-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Osteosarcoma (OS) is the prevalent form of primary bone cancer among adolescents, but the 5-year overall survival rate for patients with a metastatic or recurrent OS is under 20%. Angio-associated migratory cell protein (AAMP) is known to be a key regulator of cellular migration, yet its role in the context of OS metastasis has yet to be firmly established.<bold...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 777880f6-076b-5ea8-93f7-5a565a40c4c2
DOI: 10.21203/rs.3.rs-1208015/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Angio-Associated Migratory Cell Protein (AAMP) Regulates the Hippo/YAP Pathway and Mitochondrial Functionality to Drive Osteosarcoma MetastasisDOI 10.21203/rs.3.rs-1208015/v1Read

Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunitiesSemantic proximity Read

Analysis of publicly available transcriptomic data to identify key genes and pathways associated with osteosarcoma metastasisSemantic proximity Read

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma.Semantic proximity Read

Exploring the key genes and pathways of osteosarcoma with pulmonary metastasis using a gene expression microarraySemantic proximity Read

New insights into the role of mitophagy related gene affecting the metastasis of osteosarcoma through scRNA-seq and CRISPR-Cas9 genome editingSemantic proximity Read

Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonizationSemantic proximity Read

Exploration of Various Roles of Hypoxia Genes in OsteosarcomaSemantic proximity Read

Angiogenesis-relevant lncRNA signature for osteosarcoma: prospects for prediction of clinical outcomes and immunotherapeutic efficacySemantic proximity Read

ANGPTL4 Negatively Regulate the Progression of Osteosarcoma by Remodeling Branched-Chain Amino Acid MetabolismSemantic proximity Read

Intrinsic epigenetic state of primary osteosarcoma drives metastasisSemantic proximity Read

Upregulated ATG4B Predicts Poor Prognosis and Correlates with Angiogenesis in OsteosarcomaSemantic proximity Read

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypesSemantic proximity Read