Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy.

Nature cell biology - 1 Mar 2026

Chica Nathalia, Andersen Aram N, Orellana-Muñoz Sara, Garcia Ignacio, P Aurélie Nguéa, Nakken Sigve, Ayuda-Durán Pilar, Håkensbakken Linda, Schultz Sebastian W, Rødningen Eline, Putnam Christopher D, Zucknick Manuela, Rusten Tor Erik, Enserink Jorrit M

Abstract excerpt

Recycling of cellular components through autophagy maintains homeostasis in changing nutrient environments. Although its core mechanisms are extensively studied, understanding of its systems-wide dynamic regulation remains limited, particularly regarding how autophagy is inactivated once nutrients are restored. Here we mapped the genetic network that controls activation and inactivation of autophagy during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagosomes
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Deep Learning

Share to Gene Regulatory Networks

Share to Genomics

Share to Nitrogen

Source

Open in PubMed Open full text

Identifiers

PMID: 41826700
DOI: 10.1038/s41556-025-01837-0
PMCID: PMC12992121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy.PMID 41826700Read ↗

Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagySemantic proximity Read ↗

Autophagy Plays Prominent Roles in Amino Acid, Nucleotide, and Carbohydrate Metabolism during Fixed-Carbon Starvation in Maize.Semantic proximity Read ↗

Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation.Semantic proximity Read ↗

The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein.Semantic proximity Read ↗

Image-based temporal profiling of autophagy-related phenotypesSemantic proximity Read ↗

Quantitative and temporal measurement of dynamic autophagy ratesSemantic proximity Read ↗

C-COMPASS: A Neural Network Tool for Multi-Omic Classification of Cell CompartmentsSemantic proximity Read ↗

Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Autophagy dark genes: Can we find them with machine learning?Semantic proximity Read ↗

Sulfur availability regulates plant growth via glucose-TOR signaling.Semantic proximity Read ↗

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons.Semantic proximity Read ↗

Quantitative imaging of species-specific lipid transport in mammalian cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.