Article

c-MYC is Transcribed in a Circadian Manner and Acts a Clock Disruptor whose Timing Minimizes its Impacts

2026-05-29

Abstract excerpt

The c-MYC proto-oncogene regulates cellular proliferation, and its aberrant expression drives a range of human cancers. It also has a bidirectional regulatory relationship with the mammalian core circadian clock, with emerging evidence suggesting that MYC overexpression leads to clock disruption and loss of rhythms. While prior studies have probed MYC’s role in clock disruption by overexpressing or mutating the...

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Identifiers and source

Literature Corpus work: 771b09aa-561f-5ffd-85a9-bb285218ed58
DOI: 10.64898/2026.05.26.727929

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