Back to search

Article

Translation of a human induced pluripotent stem cell-derived ovarian support cell product to a Phase 3 enabling clinical grade product for<i>in vitro</i>fertilization treatment

2025-04-05

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) show great promise in the development of novel strategies to mitigate reproductive diseases and promote successful reproductive outcomes. Recently, a novel approach for the fast and efficient differentiation of ovarian support cells (OSCs) to generate a versatile platform for basic research and clinical applications was demonstrated. This study details the clinical pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
76f90414-ad1b-51f8-9df6-56160e80f6f5
DOI
10.1101/2025.04.02.25324702
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Translation of a human induced pluripotent stem cell-derived ovarian support cell product to a Phase 3 enabling clinical grade product for<i>in vitro</i>fertilization treatmentDOI 10.1101/2025.04.02.25324702
Improved rescue of immature oocytes obtained from conventional gonadotropin stimulation cycles via human induced pluripotent stem cell-derived ovarian support cell co-cultureSemantic proximity
Human induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation <i>in vitro</i> after abbreviated gonadotropin stimulationSemantic proximity
Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational studySemantic proximity
Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulationSemantic proximity
Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytesSemantic proximity
Oocyte Arrested at Metaphase II Stage Were Derived From Human Pluripotent Stem Cells in VitroSemantic proximity
FGF2, LIF, and IGF1 (FLI) supplementation during human in vitro maturation enhances markers of gamete competenceSemantic proximity
Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomesSemantic proximity
Good Manufacturing Practice–compliant human induced pluripotent stem cells: from bench to putative clinical productsSemantic proximity
An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity
Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patientsSemantic proximity
An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity
Select a neighboring publication to make it the new centre.