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FGF2, LIF, and IGF1 (FLI) supplementation during human in vitro maturation enhances markers of gamete competence

8 Aug 2023

Abstract excerpt

STUDY QUESTION: Does a chemically defined maturation medium supplemented with FGF2, LIF, and IGF1 (FLI) improve in vitro maturation (IVM) of cumulus-oocyte complexes (COCs) obtained from children, adolescents, and young adults undergoing ovarian tissue cryopreservation (OTC)? SUMMARY ANSWER: Although FLI supplementation did not increase the incidence of oocyte meiotic maturation during human IVM, it significantly...

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PMID: 37608600
DOI: 10.1093/humrep/dead162

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