Article

Electric-field induced sleep promotion and lifespan extension in Gaucher’s disease model flies: Association with improving ER stress and autophagy

2024-04-02

Abstract excerpt

Gaucher’s disease (GD), one kind of genetic disease, is characterized by a mutation in metabolic enzyme, glucocerebrosidase (GBA), leading to accumulation of its substrate, glucosylceramide in tissues. We previously discovered that the minos -inserted mutation of the GBA gene in fruit flies, Drosophila melanogaster , reproduced human GD characteristics and can be used as a promising model for molecular mechanis...

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Literature Corpus work: 76e4239e-4ea9-54e3-b570-cbab02c1eb22
DOI: 10.1101/2024.04.01.587515

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