Article

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency by Modulating Glutamate Transport

2022-04-06

Abstract excerpt

LRP1, the low-density lipoprotein receptor 1, would be a novel candidate gene of Epilepsy according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in Epilepsy and whether Beta-hydroxybutyrate, the principal ketone body of the ketogenic diet, can treat epilepsy caused by LRP1 deficiency. UAS/GAL4 system was used to establish different genotype models. Flies were given...

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Literature Corpus work: 3b2629d5-48d5-5f2c-97b1-e18b2bd1efec
DOI: 10.21203/rs.3.rs-1244600/v2

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