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Article

The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity.

Journal of molecular biology - 1 Oct 2026

Rogasevskaia Tatiana, Jalloul Ali H, Szerencsei Robert T, Major Daniel, Visser Frank, Schnetkamp Paul P M

Abstract excerpt

Human pigmentation is determined by melanosome development and melanin production through melanogenesis, a process regulated by melanogenic proteins. A single nucleotide polymorphism (A111T) in the SLC24A5 gene, which encodes the K⁺-dependent Na⁺/Ca2⁺ exchanger NCKX5, is a major determinant of normal variation in human skin and iris color. Despite the suggested role of NCKX5 in skin pigmentation, its ion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42462966
DOI: 10.1016/j.jmb.2026.169947

Genes

SLC24A5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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