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Repeat Systemic Delivery of Cross-Neutralization Resistant Synthetic Vesiculoviruses Immunomodulates the Tumor Microenvironment

2025-08-03

Abstract excerpt

The clinical efficacy of systemic oncolytic virotherapy (OV) is constrained by the rapid development of neutralizing antibodies (nAbs), which prevent repeat systemic administration, a critical barrier to sustained anti-tumor immunity. Vesiculoviruses offer potent oncolytic and immunogenic potential. However, leveraging their serological diversity for repeat dosing remains unexplored. We generated a library of chim...

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Identifiers and source

Literature Corpus work
76b518a3-4f8d-5efd-b5a4-48f1883b2e62
DOI
10.1101/2025.08.01.668184
Open publication

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Repeat Systemic Delivery of Cross-Neutralization Resistant Synthetic Vesiculoviruses Immunomodulates the Tumor MicroenvironmentDOI 10.1101/2025.08.01.668184
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