Article

Characterization of STRN::ALK Fusions in Oncocytic Thyroid Tumors Reveals Fusion Architecture as a Determinant of Functional ALK Activation

2026-04-23

Abstract excerpt

<title>Abstract</title> <p> Oncocytic thyroid carcinoma (OTC) represents a distinct subtype of thyroid cancer characterized by marked genomic complexity and frequent resistance to radioactive iodine therapy, highlighting the need for refined molecular stratification. Rearrangements involving <italic>ALK</italic> gene, particularly <italic>STRN::ALK</italic> fusions, have been described in thyroid neoplasia a...

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Literature Corpus work: 769e80c4-94f6-58e2-9a44-9fc164f736b0
DOI: 10.21203/rs.3.rs-9360178/v1

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