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Article

Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Chu Ying-Hsia, Wirth Lori J, Farahani Alexander A, Nosé Vânia, Faquin William C, Dias-Santagata Dora, Sadow Peter M

Abstract excerpt

The discovery of actionable kinase gene rearrangements has revolutionized the therapeutic landscape of thyroid carcinomas. Unsolved challenges include histopathologic recognition of targetable cases, correlation between genotypes and tumor behavior, and evolving resistance mechanisms against kinase inhibitors (KI). We present 62 kinase fusion-positive thyroid carcinomas (KFTC), including 57 papillary thyroid...

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Identifiers

PMID: 32737449
DOI: 10.1038/s41379-020-0638-5
PMCID: PMC7688509

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