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RET Gene Fusions in Malignancies of the Thyroid and Other Tissues

15 Apr 2020

Abstract excerpt

Following the identification of the BCR-ABL1 (Breakpoint Cluster Region-ABelson murine Leukemia) fusion in chronic myelogenous leukemia, gene fusions generating chimeric oncoproteins have been recognized as common genomic structural variations in human malignancies. This is, in particular, a frequent mechanism in the oncogenic conversion of protein kinases. Gene fusion was the first mechanism identified for the...

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PMID: 32326537
DOI: 10.3390/genes11040424

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