Article

THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours

2022-05-18

Abstract excerpt

Gastrointestinal stromal tumour (GIST) is the most common mesenchymal tumour of the gastrointestinal tract and is characterized by activating mutations of the KIT or PDGFRa receptor tyrosine kinases (RTKs). Despite the clinical success of tyrosine kinase inhibitors (TKIs), more than half of GIST patients develop resistance due to a second mutation. Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of CDK-a...

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Identifiers and source

Literature Corpus work: 76741f48-e087-5b1f-b3a2-c6007638fdea
DOI: 10.21203/rs.3.rs-1641526/v1

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