Article

Interactions in CSF1-driven Tenosynovial Giant Cell Tumors

2022-06-03

Abstract excerpt

The majority of cells in Tenosynovial Giant Cell Tumor (TGCT) are macrophages responding to CSF1 that is overproduced by a small number of neoplastic cells with a chromosomal translocation involving the CSF1 gene. Treatment with inhibitors of the CSF1 pathway has been clinically effective. An autocrine loop was postulated where the neoplastic cells are stimulated through the CSF1 receptor (CSF1R) expressed on the...

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Literature Corpus work: 7670079f-b0bd-5c98-a76a-a0cea123a553
DOI: 10.1101/2022.06.01.494428

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