Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages

25 Aug 2021

Abstract excerpt

Abstract Macrophages can be co-opted to contribute to neoplastic, neurologic, and inflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R)-dependent macrophages and other inflammatory cells can suppress the adaptive immune system in cancer and contribute to angiogenesis, tumor growth, and metastasis. CSF1R-expressing osteoclasts mediate bone degradation in osteolytic cancers and cancers that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Musculoskeletal synovial abnormalities and treatments
Share to Sarcoma Diagnosis and Treatment
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34433663
DOI: 10.1158/1535-7163.mct-21-0361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by MacrophagesPMID 34433663Read ↗

Novel CSF1R-positive tenosynovial giant cell tumor cell lines and their pexidartinib (PLX3397) and sotuletinib (BLZ945)-induced apoptosisSemantic proximity Read ↗

Interactions in CSF1-driven Tenosynovial Giant Cell TumorsSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of BoneSemantic proximity Read ↗

Expanding the molecular spectrum of tenosynovial giant cell tumorsSemantic proximity Read ↗

Detection of CSF1 rearrangements deleting the 3′ UTR in tenosynovial giant cell tumorsSemantic proximity Read ↗

Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone.Semantic proximity Read ↗

Giant cell tumor of bone: updated molecular pathogenesis and tumor biology.Semantic proximity Read ↗

Clinical Characteristics and Treatment Patterns of Tenosynovial Giant Cell Tumor in Japan: An Analysis of the Japanese Bone and Soft Tissue Tumor RegistrySemantic proximity Read ↗

DDX3 Regulates the Innate Immune Response to Bone SarcomasSemantic proximity Read ↗

Molecular Profiling of Atypical Tenosynovial Giant Cell Tumors Reveals Novel Non-CSF1 FusionsSemantic proximity Read ↗

Rescue of In Vitro Models of CSF1R-Related Adult-Onset Leukodystrophy by Iluzanebart: Mechanisms and Therapeutic Implications of TREM2 AgonismSemantic proximity Read ↗

Immunohistochemical Characterization of Feline Giant Cell Tumor of Bone (GCTb): What We Know and What We Can Learn from the Human CounterpartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.