Article
The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.
eLife - 14 Aug 2018
Caldwell Alison, Coleby Rachel, Tovar Cesar, Stammnitz Maximilian R, Kwon Young Mi, Owen Rachel S, Tringides Marios, Murchison Elizabeth P, Skjødt Karsten, Thomas Gareth J, Kaufman Jim, Elliott Tim, Woods Gregory M, Siddle Hannah Vt
Abstract excerpt
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1). Here we show that in contrast to DFT1, DFT2 cells express major histocompatibility complex (MHC) class I molecules, demonstrating that loss of MHC is not necessary for the emergence of...
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